Question

When the juxtaglomerular cells in the kidney are, they produce and secrete the enzyme renin into the blood. what subsequent changes take place by this mechanism?

Answer 1

The juxtaglomerular cells near each kidney are stimulated to secrete the enzyme renin into the blood. Renin circulates throughout the body and converts angiotensinogen, made in the liver, into angiotensin I. In the lungs, angiotensin I is converted by hydrolysis to angiotensin II. Angiotensin II acts on the adrenal cortex to stimulate production of aldosterone. Aldosterone acts on the juxtaglomerular cells to increase sodium and water retention and to stimulate or depress further renin secretion, completing the feedback system that automatically readjusts homeostasis.