Answer: Europe.
Explanation: North America and South America.
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Answer:
Betteridge's law of headlines is an adage that states, Any headline that ends in question mark can be answered by the word no which was named after Ian Betteridge. A British technology journalist who wrote about it in 2009.
The themes that played a major role in changing the world between 1450 and 1750 was that plants were being spread together with animals and diseases between the Americas and the rest of the world; mainly Europe. Especially famous are cases where European contact wiped out whole villages and tribes of native American people because they were unable to cope with the bacteria and viruses.