Question

There are two main types of adrenergic receptors: the α and β- adrenoceptors. noradrenaline shows slight selectivity for the α receptor, whereas isoprenaline shows selectivity for the β adrenoceptor. adrenaline shows no selectivity and binds equally well to both the α and β-forms of the adrenoceptors. draw the chemical structures for noradrenaline, isoprenaline, and adrenaline. suggest an explanation for these differences in selectivity relative to the binding site of each receptor.

Answer 1

The different adrenal hormones show selectivity for different types of adrenergic receptors. This may be because the chemical structures of the adrenal hormones are such that binding is biochemically easier for the hormones at the receptors to which they show a selective affinity.