Protein-protein interactions within the CARMA1-BCL10-MALT1 complex:
- The T-cell receptor and B-cell receptor-dependent NF-B induction and lymphocyte activation are mediated by the CBM complex, which is made up of the proteins CARMA1, BCL10, and MALT1.
- Each of the proto-oncoproteins CARMA1, BCL10, and MALT1 is a somatic gain-of-function mutation or chromosomal translocation, and dysregulation of CBM signaling is a characteristic of numerous lymphoid malignancies, including Activated B-cell Diffuse Large B-cell Lymphoma.
- Moreover, a number of immunological dysregulation diseases have been linked to both gain- and loss-of-function germline mutations in CBM complex proteins.
- Over the past ten years, careful examination of the interactions of CBM components has yielded a wealth of detailed structural knowledge.
- Here, we discuss important discoveries about the molecular nature of these protein-protein interactions that have helped the research develop a detailed understanding of how these proteins come together to form high-order filamentous CBM complexes.
- Approaches to therapeutic suppression of the CBM complex have thus far centered on obstructing MALT1 protease activity in order to treat lymphoid malignancy and/or autoimmunity.
- The structural effects of MALT1 protease inhibitors on significant protein-protein interactions are also reviewed in detail.
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Answer:
42 kg.m/s if the two are moving in the same direction
Explanation:
momentum formula: p=mv
22kg.m/s+20kg.m/s= p
42kg.m/s=p
the momentum of both objects=42 kg.m/s
Answer:
<u>50%</u>
Explanation:
<em>Since</em> it was not a case of a Lettuce seed exposed first to <em>red light</em> and then to <em>far-red light</em> which will very likely not germinate because Pr (chromoprotein inactive form) absorbs red light efficiently, the light absorbed will convert a high proportion of the molecules to the Pfr (chromoprotein active form), thereby inducing germination. So there is a 50/50 percentage chance of of germination.
After wind erosion, the igneous rock turns to sediment. It may be dropped into a river where the sediments go through cementation and compaction. Then it become a sedimentary rock. This cycle goes on forever. It is called the rock cycle.
