Cystic fibrosis is an inherited respiratory disorder in which the mucociliary escalator no longer functions because of the prese
nce of excessively dense and viscous mucus. Which of the following components of the respiratory system are affected by cystic fibrosis? A. oblet cells
B. cilia
C. lungs
D. All of the listed responses are correct.
Cystic fibrosis is a genetic disease caused by the mutation in the CF gene located on chromosome 7 which codes for the CFTR protein.
Cystic fibrosis transmembrane regulator protein or CFTR encoded protein regulates the movement of the water and chloride and sodium ions in and out of the cell.
The mutated gene forms abnormal protein which disrupts the movement of the ions and water in and out of the cell.
As a result of thick, the person develops thick and sticky mucus in the respiratory organs, especially in the lungs. Other organs of the body are also affected.
Genetic predisposition to an inherited disorder an increased likelihood of developing the particular <span>disea</span>se<span> based on a person's </span>genetics.<span> Genetic testing for predisposition to an inherited disorder in a minor child would be considered reasonable </span>when the risk is high and prophylaxis to reduce disorder severity is available.
If there is no dominant allele for a trait present on a homologous chromosome to mask the recessive allele, the recessive phenotype will be expressed. In this case, the gene is located on the Z chromosome. In an individual with a ZW genotype (female) there is no homologous Z partner, meaning whatever allele is present on the solitary Z chromosome will be expressed.
An anticodon is a trinucleotide sequence complementary to that of a corresponding codon in a messenger RNA (mRNA) sequence. An anticodon is found at one end of a transfer RNA (tRNA) molecule.
