Diabetes is a condition that involves abnormal glucose levels in the blood (blood sugar). Type 2 diabetes result from the impaired uptake of glucose by the body cells for generation of energy, which caused by the cells being insenstitive to insulin hormone. It is caused by one being over weight, lack of exercise among other factors. Pedometers are gadgets that counts the steps taken by individuals by detecting motion or movement of hands and hips. Pedometers use by diabetic people has been found to be beneficial in a number of ways; first they help individuals to exercise more, pedometers are useful in evaluating and setting fitness objectives which end up helping the patients exercise thus reducing the risk of diabetes. secondly use of pedometers has seen weight and BP reduction . Hence due to these and many other benefits pedometers are useful in type 2 diabetic patients.
Answer:
In one way, the existence of a nonsense mutation would lead to the generation of a premature termination codon that will be identified by the RNA polymerase as a termination sequence encouraged by the activity of Rho factor to dissociate ribosome, thus, discharging RNA polymerase and preventing further transcription mechanism making the transcription of the downstream sequence impossible.
For the second way, there is a need to consider that the mechanism is taking place post-transcriptionally. Thus, the effects should be devised after transcription has taken place and the only fate lies in the mechanism encouraged by the RNA dependent RNA-polymerase. However, for this to take place, the event of genetic recombination can also be taken into account leading to the appearance of the faulty gene in the sequence. Apart from this, the open reading frame is required to be co-expressive that would be the most suitable factor, which determines whether the downstream sequences will be transcribed or not post nonsense mutation.
However, the total change relies upon the fact that the mutation is taking place artificially or is induced naturally. One more thing to consider is that there is an existence of another gene known as MCB 354, which is encrypted by another gene and is probably monitored by another promoter sequence. Thus, co-expression would probably be the mechanism in terms of the rho-dependent termination.
Komodo dragons can reproduce both sexually and asexually depending on the environment. They can do this because of Parthenogenesis (Parthenogenesis is a natural form of asexual reproduction in which growth and development of embryos occur without fertilization. In animals, parthenogenesis means the development of an embryo from an unfertilized egg cell.)
