I believe the answer is b.
Answer:
A pronoun can be used as the preposition of a verb.
A pronoun placed before a noun don´t shows ownership and a pronoun cannot be used as the subject of a verb.
<span>The many organ system changes that occur because of alcohol take toll on the kidneys, which cannot function optimally. This failure leads to retention of body fluids. Symptoms include swelling of body tissues, such as feet, legs, hands, and face. Kidney failure is inevitable with end-stage liver disease.</span>