The coated beads of the drugs could possibly result in toxicity.
There are a few reasons why the capsules should not be crushed. Crushing or opening it may cause side effects, may prevent the medicine from working properly or may slow down the process of recovery from illness.
The same ligand can bind to different receptors causing different responses (e.g.. acetylcholine). On the other hand, different ligands binding to different receptors can produce the same cellular response (e.g. glucagon, epinephrine).