The induced-fit model includes the change in the conformational site of the substrate and enzyme. It is done till the enzyme completely binds the substrate. This will then activates the enzyme to perform its work.
<h3>What is induced fit theory?</h3>
Induced fit theory or model suggest that the activation site of enzymes and the binding site of substrates undergo some conformational changes to fit into each other.
This binding results in activation of the enzyme and as the enzyme has a three-dimensional tertiary structure, this would help it to get fitted into the substrate.
Thus, with reference to the induced fit model tertiary structure of enzyme facilitates its function as a biological catalyst.
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Astrocytes are a group of cells with functional characteristics and distinctive morphological that vary within specific areas of the brain.
For healthy brain function, astrocytes are essential. those become reactive in the case of Alzheimer's disease, which impacts the signaling properties. while experimenting, there was the measurement for instinctive calcium transients ex vivo in hippocampal astrocytes in brain slices containing the dentate gyrus of 9-month-old and 6-month-old APPswe/PSEN1dE9 mice. when they investigated the duration of calcium transients and frequency concerning amyloid-β (Aβ) pathology, the proximity of the astrocyte to Aβ plaques, and aging. there was no change in spontaneous calcium-transient properties of 6M APP/PS1 astrocytes compared to wild-type astrocytes, whereas there was hyperactivity in 9M APP/PS1 astrocytes compared to wild -type, which were longer in duration, also there was an effect of aging too, there was an increase in calcium in the 9-month astrocytes than to the 6-month astrocytes, also there was an increase in the calcium waves in the 9-month astrocytes because of the increase network activity. The findings were that the change in calcium signaling in individual astrocytes of APP/PS1 mice is because of both pathology and aging but these don't have any impact on changes in the astrocyte network activity, which leads to helping to understand changes in neuronal physiology.
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The statement above is TRUE.
RNA hydrolysis is a reaction in which a phosphodiester bond in the sugar phosphate backbone of RNA is broken, thus cleaving the RNA molecule.
This reaction is made possible in RNA because the ribose sugar in RNA has hydroxyl group at the two prime position.