Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
<span>The MOSQUITO spreads more parasitic diseases to humans than any other vector.
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Your question: <span>Assume that a cross is made between aabb and aabb plants and that all the offspring are either aabb or aabb. these results are consistent with ________.
Your answer: </span>Assume that a cross is made between aabb and aabb plants and that all the offspring are either aabb or aabb. these results are consistent with absolute linkage in cis.
Any queries ^?
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Answer:
Its location.
Explanation:
The main difference between pyrogenesis and setting garbage on fire in a landfill is that pyrogenesis process occurs on the surface whereas garbage on fire in a landfill occurs inside the soil at certain depth. Pyrogenesis is an extreme thermal process that converts organic matter into gas made up of hydrogen and oxygen whereas garbage on fire in a landfill decomposes garbage that breaks down materials in simpler substances.
Answer:
There were 1.2 billion persons in the year 1850
Explanation: