Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
Muscle cells extended called nervous muscle fibre tissue unit of muscle fiber
A cellular membrane separates the interior of all cells from the outside environment.
Blade
Thin, flattened section of a plant leaf that collects sunlight
Petiole
Thin stalk by which a leaf blade is attached to a stem
Mesophyll
Specialized ground tissue that makes up the bulk of most leaves; performs most of a plant's photosynthesis
Palisade Mesophyll
Layer of tall, column-shaped mesophyll cells just under the upper epidermis of a leaf
Spongy Mesophyll
Loose tissue beneath the palisade layer of a leaf
Stoma
Opening in the underside of a leaf that allows carbon dioxide and oxygen to diffuse into and out of the leaf
Guard Cell
Specialized cell in the epidermis of plants that controls the opening and closing of stomata by responding to changes in water pressure
Transpiration
Loss of water from a plant through its leaves
(Got this from my textbook so here)
By predicting bad weather and keeping people safe during danger
Btw, i think you meant meteorologists.
