Answer: A question that I am always reflecting about is: Do animals have thoughts¿ I have a little cat, and whenever I look at it, I reflect and wonder about the possibility of animals having thoughts. When it sees or smells anything how do this process works into their heads.
Ultraviolet radiation may increase when there is an increase in sunspots
Animals and plants need to get rid of carbon dioxide gas through a process called respiration. Carbon moves from fossil fuels to the atmosphere when fuels are burned. When humans burn fossil fuels to power factories, power plants, cars and trucks, most of the carbon quickly enters the atmosphere as carbon dioxide gas.
Answer and Explanation:
- The normal function of the CFTR protein is to transport Cl- ions as it works as a chlorine channel regulated by AMPc and by protein kinase K (PKA). CFTR is also a regulator for other ionic channels. The CFTR protein expresses in the luminal portion of the secretory and absorptive epithelial membranes and they have an important role in the secretion of electrolytes activated by AMPc and intracellular calcium. This protein constitutes the way out of Cl-from the lumen. Apart from its secretory function, CFTR protein also regulates the function of the electrolyte by inhibiting the epithelial Na+ channel activity in absorptive epithelial cells from the colon and aerial vias, and by activating the Na+ channel in sudoriparous conducts.
- Given that defects on the CFTR protein take to a defective regulation in the Na+ channel, the cystic fibrosis characterizes for alterations in electrolytes secretions and absorption. There are two important physiopathological mechanisms:
1) altered Cl- secretion in submucous glands,
2) increased Na+ absorption and consequent electrolytes hyperabsorption in the superficial epithelium.
Patients with cystic fibrosis are incapable of increasing their secretory transport. On the contrary, the increased epithelial Na+ conductance in apical membranes, the paracellular permeability to Cl- and elevated permeability to water, all together, do not allow a higher osmotic transepithelial gradient, which leads to a hyperabsorption in the patient epitheliums. The superficial liquid layer in the aerial vias decrease, mucous glands are not released from the mucus and the mucociliary clearance is strongly altered in aerial vias.
- The Lumacaftor (VX-809) is a drug directed to type II mutations. These mutations are present in an elevated number of patients with CF and include Phe508del that is the most frequent mutation. Ivacaftor (VX-770), is a drug directed to type III mutations in homozygote patients for Phe508del.
Given that lumacaftor helps the movement of Phe508del CFTR to the cell surface and the ivacaftor increases the opening time and the Cl- conductance through the epithelial cell, the treatment can be possible with a combination of the two drugs.
Another alternative compound is VX-661 that <u>is being studied</u>. Its efficiency is being evaluated by itself and together with ivacaftor.
Its estimated that during sprint events approximately 95% of energy production comes via the anaerobic system (85% phosphate, 10% anaerobic glycolysis), and only 5% from aerobic oxygen. Thus, the 100m sprint is an anaerobic event relying heavily on energy supply from the ATP-PC system!
