Prader-Willi syndrome (PWS) is a gentic disorder which has an impact on numerous physiological systems. PWS affected individuals (specifically babies) experience delayed growth, significant hypotonia (low muscle tone), and feeding issues. It does effect circadian rhythms in mice models.
SNORD116, often referred to as HBII-85, is a non-coding RNA (ncRNA) molecule that contributes to the alteration of other small nuclear RNAs (snRNAs). Unlike the majority of other snoRNAs, SNORD116 is not significantly complementary to ribosomal RNA and is expressed widely in the brain (but not in PWS patients).
According to the studies, SNORD116 cause sleep defect in patients with Prader-Willi syndrome. Same observation was seen in mouse models too. Paternal expression of SNORD116 is thought to be a potential gene for the sleep disruptions/circadian rhythm’s that the majority of PWS sufferers.
To learn more about circadian rhythm click here
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Answer:
what type of qustion is this
Explanation:
Answer:
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Answer:
C
Explanation:
I think its C . A transcriptional repressor usually represses the transcription pathway when its active. According to the question, the repressor is not usually active until an effector molecule binds to it making it active and blocking the transcription pathway. So if the region where the effector binds on the repressor is mutated i.e. it turns nonfunctional that means the effector cannot bind to repressor which means repressor cannot become active to block transcription which in turn increases the transcription of gene A because repressor cannot repress it since it is inactive due to its inability to bind to the effector.
ALOT of words please lmk if it makes sense
All the spheres interact with other spheres. For example, rain (hydrosphere) falls from clouds in the atmosphere to the lithosphere and forms streams and rivers that provide drinking water for wildlife and humans as well as water for plant growth (biosphere).
