The correct answer is: B) binding to their substrate
The catalytic mechanism of an enzyme starts when the substrate binds to its active site (specific region of an enzyme). There is a theory (lock and key) that explains the mechanism of this binding: the lock is the enzyme and the key is the substrate and only if they fit the enzyme will work. The binding of the substrate to the enzyme causes conformational changes of the enzyme, and as a result, products are formed. The products are then released from the surface of tat enzyme. The enzyme is regenerated for another reaction cycle.
Liquid as first of all, the particles aren't compact ( which would mean solid) nor are they spread out ( which would mean gas) nor is it plasma as we aren't given protons or electrons.