Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The answer is D) the organ system.
Answer:
- GgLl x Ggll ---> grey long x grey short
- Ggll x Ggll ---> grey short x grey short
- GgLL x ggLL or GgLL x ggLl ---> black long x grey long
- GGLl x GGLl or GGLl x GgLl ---> grey long x grey long
- GGLl x GGll or GgLL x GGll ---> grey short x grey long
Explanation:
Due to technical problems, you will find the complete answer and explanation in the attached files
Answer:
<u>C. Broca's Area</u>
Explanation:
Broca’s area is located in the front part of the left hemisphere of your brain. It has an important role in turning your ideas and thoughts into actual spoken words. Broca’s area is the most active Source right before you speak.
Broca’s area also helps to pass the information to another part of your brain called the motor cortex, which controls the movements of your mouth. It’s named after a French doctor, Pierre Paul Broca, who discovered the region of the brain in 1861.
<u>Hope this helps!</u>
