A dodecahedron has 12 regular pentagonal faces, 20 vertices, and 30 edges. Three faces meet at each vertex.The faces of the dodecahedron are pentagons.<span>A dodecahedron is a polyhedron with 12 faces . A dodecahedron is a three-dimensional shape having twelve plane faces. </span>
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
Must have lived before.
Explanation:
For an organism to be classified as once living, an object must have been part of a living organism or is now dead. When a flower is plucked from a plant it is hard to distinguish between when it is considered alive and when it is now considered once living. An example of a nonliving object is an apple or a dead leaf.Apr 22, 2013
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1. True.
2. Given: Mass = 30 Kg
Acceleration = 2.0m/s2
Force= mass x acceleration
Force= 30Kg x 2.0 m/s2
Force= 120 N
3. Given : Mass = 30 Kg
Force= 180 N
Force = Mass x Acceleration
Acceleration = Force / Mass
= 180 N / 30 Kg
Acceleration = 6.0 m/s2
Answer:
It is important to do this to test your theory multiple times, so that you can see what effect the drop has on it when doing this multiple times. The numbers were slightly different because the recordings will not always be the same.
Explanation:
