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The abiotic factors will define which organisms are able or not to live in a specified place. The living organisms will constitute the biotic factors, which define if and how can an organism live in a specified environment. So, the abiotic factors are controlling the biotic factors of an environment.
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Humans burn fossil fuels, clear trees, change land use, creating smog that traps the carbon in the Earth's atmosphere, leading the oceans to absorb the heat and eventually end up with global warming and ocean acidification.
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The human digestive system can fail if you eat something harmful, and it can break down nutrients, techinically the digestive system can stop working if you get something like Gastoparesis, which stops the movement of food through the digestive system.
