Question

Predict how a loss of function mutation in the p53 gene is most likely to affect the cell cycle in response to DNA damage. Justify your predictions.

Answer 1

Answer:

The cell cycle of cell multiplication is regulated by three types of genes, the regulatory genes that control mutations, the generic promoters of cell replication, and genes that inhibit cell replication.

The balance between these three types of gene group are what result in a good multiplication of cells without mutations or neoplastic developments.

The p53 gene is one of the genes that is considered as the guardians of the genome, since it is in charge of corroborating and regulating mutated cells, in this way it inhibits their progression in the cell cycle by putting a stop to not replicate defective genes or genes with alterations.

Explanation:

The p53 gene is one of the most altered genes seen in malignant neoplasms, since by altering our guardian of the genome many mutations overlook and more carcinogenic potential will have neoplastic tissue.

In the three groups of genes that we write, all three have a fundamental roll in the cell cycle, but in order to trigger malignant neoplasms, it is necessary that there be a continuous series of gene mutations in these three groups, it is not enough with the mutation of a single gen.