* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies.
<span>There are indeed three ways to activate the complement:</span>
Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
Plantae: Autotrophic, Multi- or Monocellular, have cell walls as well as a membrane, have a chloroplast making the characteristic green color and to capture sunlight for photosynthesis. Break down generated glucose into it's components.
Animalia: Heterotrophic, Multi- or Monocellular, have a cell membrane made of a phospholipid bilayer, and many mitochondria to aid with movement energy. Feed on plants or other animals. Eukaryotic cells.
Fungi: Heterotrophic, most Multicellular, have a rigid cell wall made of chitin, specialized cells to aid with decomposition of dead organic matter. Eukaryotic cells.
Protista: Can be plant-like, animal-like, or fungus-like. Most are single-celled, may be chemosynthetic or photosynthetic. Eukaryotic cells.
Archeabacteria: Prokaryotic. Do not have nuclei or membrane-bound organelles. Move around using a flagellum to propel itself. Lives in mainly fluid environments (air, water). Separated from Eubacteria due to it's high tolerance of extreme conditions, such as high salinity, no oxygen, burning heat, or freezing cold. Can be chemosynthetic or anaerobic, as well as aerobic.
Eubacteria: Normal, everyday bacteria. Prokaryotic, chemosynthetic, anaerobic, or aerobic. Do not have nuclei or membrane-bound organelles. Mobile using a flagellum to propel itself.
A) Vibrations
Sounds vibrate the eardrum
