Answer:
Explanation:
The switch from glutamic acid to valine in position 6 of hemoglobin (HB) forms the basis of sickle cell anemia disease pathology.
Valine is hydrophobic and it's chain is shorter than glutamic acid. The lack of the carboxylic acid and shortness of valine will result in loss of the ionic interactions formed between the glutamic acid's carboxylic group and other amino acids. A hydrophobic cavity will form in the beta sheet of HB due to the short and hydrophobic structure of valine. For these reasons, the HB molecule will be less stable and insoluble in water. The insolubility is thought to be caused by fibril formation between the valine interacting with hydrophobic pocket residues of the adjacent HB molecule. This would in turn affect binding of oxygen to HB.
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Answer:
Aspirin works by inhibiting the production of prostaglandins. Aspirin inhibits the formation of prostaglandins by combining with the COX enzymes. Prostaglandins function as messenger molecules to monitor different physiological procedures in distinct regions of the body. One of the prime activities of prostaglandins is to stimulate inflammation and pain.
Prostaglandins are also the essential controller of platelet aggregation. By changing the COX enzymes inside the platelets, aspirin makes platelets to lose the stickiness, which is required to instigate clotting of blood.
There are two forms of cyclooxygenase, that is, COX-1 and COX-2. COX-1 generates prostaglandins and COX-2 mediates pain and swelling in response to tissue injury. Aspirin prevents both COX-1 and COX-2 functioning, while COX-2 is the therapeutic target of the drug.
However, it is the association of aspirin with COX-1 in the gastrointestinal tract, which results in the unwanted side effects of the drug. COX-1 is required to sustain a thick lining of the stomach. As aspirin inhibits the COX-1 enzyme, thus, the continuous use of the drug can result in the thinning of mucus, which safeguards the stomach from gastric juices.
In such cases, stomach bleeding, ulcers, and in certain situations perforation of the stomach can take place. Therefore, aspirin exhibits both bad and good effects.
Unicellular prokaryotes are called bacteria.
