First pass metabolism of a drug is said to occur when the concentration of a drug that is administered orally is significantly reduced before it reaches the systemic circulation.
First pass metabolism usually occur in the liver.
The routes of drug administration that avoid complete first pass metabolism are: sublingual, transdermal, rectal and inhalation.
My opinion is that EVEN IF there is anything that humans can do to save our species,
we will argue, debate, play politics, bask in absurd conspiracy theories, fritter around,
dilly dally, and totally ignore the urgency before us, until a time when nothing we're able
to do can any longer have any effect. And that's my opinion.
Explanation:
With continual improvements made to microscopes over time, magnification technology advanced enough to discover cells in the 17th century. This discovery is largely attributed to Robert Hooke, and began the scientific study of cells, known as cell biology.
