The answer would be Option D: more bone
Family
Friends
that’s it lol
The leading cause is garbage and waste from people.
Let us look at the what, why and how of studying extreme places like the deep earth and the deep space. Scientists need to figure out as to 'what' they want to look at such places, be it a new exotic creature or bio-genesis (birth of life). Unless there are several testable hypothesis constructed, such a study cannot begin. The 'why' aspect deals with the purpose of such research and expeditions. Is it of any use to the humans, or will it improve our current understanding of a phenomenon? The 'how' aspect deals with the technology and the economic assistance that can help in undertaking such a research. All these are the challenges that needed to be thoroughly considered to make such a research or expedition possible.
Based on this observation you would predict that the MISFOLDED BETA AMYLOID PROTEINS COULD NOT BE REFOLDED BY THE CHAPERONE PROTEINS.
Chaperon proteins are proteins which assist newly formed proteins to form correctly. A protein that is already mis-folded can not be refolded by the chaperone proteins.