Question

Place the following events in the proper order. 1) Activation of one or more cellular signaling proteins. 2) Dissociation of Ga from the G protein complex. 3) Production of a second messenger, like cAMP. 4) Replacement of GDP by GTP on the Ga after interaction with an activated GPCR. 5) Conformational change in the Ga subunit causing a decreased affinity for the Gb g subunit. 6) Ga-subunit with its attached GTP activates an effector like adenylyl cyclase.

Answer 1

Answer:

4) Replacement of GDP by GTP on the Ga after interaction with an activated GPCR.

5) Conformational change in the Ga subunit causing a decreased affinity for the Gb g subunit.

2) Dissociation of Ga from the G protein complex.  

6) Ga-subunit with its attached GTP activates an effector like adenylyl cyclase.

3) Production of a second messenger, like cAMP.    

1) Activation of one or more cellular signaling proteins.

Explanation:

It is a signaling cascade initiated by G proteins. These G proteins function as molecular switches capable of activating signaling pathways in the presence of guanosine triphosphate (GTP), which is hydrolyzed in order to produce energy