Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Kelp populations would be entirely depleted and it would impact the sea life that thrive off of kelp as their homes and source of food. Many sea creatures use kelp as a sort of barrier to prevent bigger fish from attacking them.
Answer:
Characteristics such as appearance, reproduction, mobility, and functionality are just a few ways in which living organisms are grouped together. These specialized groups are collectively called the classification of living things.
Answer:
Because of homologous recombination
Explanation:
- When genes are establish on different DNAs or far apart on the same chromosome, they are classified self-sufficiently and are said to be unlinked.
- When genes are very close together on the same chromosome, they are said to be linked. That means that alleles, or genetic versions, that are already together on a chromosome will be inherited as a unit more often than not.
- We can see if two genes are linked, and how closely, by using data from genetic crosses to calculate the frequency of recombination.
- Using the technique of discovery recombination happenings for numerous gene pairs, we can make link maps that show the order and relative distances of the genes on the chromosome.
- When the genes are on the same chromosome but far apart, they are classified independently due to crossing (homologous recombination). This is a procedure that happens at the start of meiosis, in which homologous DNAs randomly exchange matching fragments. Crossing be able to connection new alleles in combination on the same chromosome, causing them to enter the same gamete. When the genes are far apart, the crossing occurs with sufficient frequency for all types of gametes to occur with 25% percentage frequency.
- When the genes are very close together on the same chromosome, the crossing still occurs, but the result (in terms of the types of gametes produced) is different. Instead of being classified independently, genes tend to "stay together" during meiosis. That is, alleles of genes that are already together on a chromosome will tend to pass as a unit to gametes. In this case, the genes are linked
