The build-up of fats, cholesterol, and other substances in and on the artery walls. A build up of cholesterol plaque in the walls of arteries causing obstruction of blood flow. Plaques may rupture causing acute occlusion of the artery by clot.
Mutations are permanent changes in the DNA due to changes in nucleotide sequences. Mutations that cause addition of extra nucleotides in a nucleotide sequences are known as frameshift mutations
