Answer:
The miRNAs act as post-transcriptional silencers, as they are similar to specific mRNAs and regulate their stability and translation. They are small endogenous non-coding ribonucleic acid (RNA) molecules, with about 22 nucleotides, which act as regulators of gene expression in plants and animals, at the post-transcriptional level through the cleavage of a target messenger RNA (mRNA) or repression of translation.
In general, most miRNA genes are transcribed by RNA polymerase II in the nucleus in primary miRNAs (pri-miRNAs). Individually, a pri-miRNA can produce a single miRNA or contain groups of two or more miRNAs that are processed from a common primary transcript. These long pri-miRNA are cleaved by a complex comprising the double-stranded RNAse III enzyme (DROSHA) and its essential cofactor, the binding protein DGCR8 (DiGeorge Syndrome Critical Region 8 protein) in mammals. DROSHA contains two domains of RNAse III, each of which cleaves a strand of the RNA resulting in the precursor microRNA (pre-miRNA) with about 70 base pairs, which contains a double-stranded stretch and a single-stranded loop, forming a structure in clamp. The pre-miRNA is exported to the cytoplasm by the protein exportin-5 (XPO-5), where it is cleaved by DICER1, an RNAse III that assesses the 3 'and 5' ends of the pre-miRNA, generating a mature miRNA with about 22 nucleotides. The processing of pre-miRNA by Dicer promotes the unfolding of the RNA duplex in the form of a clamp. The position in the formation of the clamp can also influence the choice of tape.
Explanation:
Answer:
1. the Western Pacific
2. Southeast Asia and the Western Pacific
Explanation:
Just took it
Answer:
The correct answer is: 25 %
Explanation:
According to Mandel's law of inheritance, the dominant allele masks the expression of the recessive allele if present together. If a couple has 3 children with brown eyes. In a monohybrid cross, the ideal phenotypic ratio of the offsprings is 3: 1 or in other words, the dominant character chances to appear is 75% in phenotype.
So, by the law of dominance of monohybrid cross the chances of the fourth child to develop blue eyes is 25%.
Thus, the correct answer is : 25 %.
Alfred Marshal was one of the most influential economists of his time and the author of the Principles of Economics book which was the principal economic textbook in England for long years. During his economic theory development, he borrowed a concept from the marginalists which is the theory of demand and the collective result of buyers who yearns services and products or the concept of scarcity.
