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Answer:
Disease affects an organism by disrupting the organism's homeostasis. Homeostasis is the process by which an organism maintains a steady internal environment (stable body temperature, blood sugar level, electrolyte balance, etc.). A disease will disrupt this process. For example, Helicobacter pylori (the bacteria responsible for most stomach ulcers in humans) disrupts homeostasis by interfering with the production of the mucus layer that protects the stomach lining cells from the hydrochloric acid in the stomach lumen.
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Answer: The troposphere.
It contains half of the earths atmosphere. Weather occurs in this layer.