Frequency of allele a1 is 75%, p=0.75 Frequency of allele a2 is 25%, q=0.25 If a population is in Hardy-Weinberg equilibrium then: p2+2pq+q2=1 <span>p2 is the frequency of genotype a1a1 (homozygous),</span> 2pq is the frequency of genotype a1a2 (heterozygous), q2 is the frequency of genotype a2a2 <span>The proportion of individuals with genotype a1a2 is then 2*0.75*0.25=0.375 (37.5%).</span>