The nucleus basically controls every activity in the cell so, the nucleus is transferring proteins, nutrients, waters and salts to provide for the cytoplasm which takes up space in the outside of the nucleus.
I am going to assume you are talking about emotion. If that is the case then it's better to let it all out, let the wall fall.
Tolerance can in fact cause an overdose, because the greater tolerance you can get the more of a certain substance your body will need eventually leading your body to take more than it can handle leading to overdose and death.
D is the rightful answer for this question. Prolonged stress can create and even promote bitter diseases such as cold, flu, and heart disease.
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I would say going outside. Their are so many things to can do outside with your family and so many games and activities for them to do something.
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Hope this helps.