Ending slavery means it will stop for sure, mean while ending the slavery trade means you won't be making more trades but slavery still exist.
Hope this helps! :)
His chief contribution was the cultivation of tabacco
The "Middle Ages" or medieval period generally refers to the entire time span between classical antiquity and the modern era in Western history. The Middle Ages lasted approximately AD 500 - 1500, from the fall of the (Western) Roman Empire to the fall of the Byzantine Empire and the discovery and colonization of the New World. The Middle Ages are often partitioned into the Early, High, and Late Middle Ages.
The Portuguese trading empire fall apart by 1500 because Portugal was a small country with few resources.
Answer:
Diseases were a huge negative impact. Diseases such as small pox and syphyllis were brought to the Americas by the Europeans and wiped out a large amount of the New World's population. While slavery had a bit of a positive light, it was mostly a negative thing! <3