Molten material is allowed to solidify into the final shape.
Casting defects occur during solidification:
Gas porosity
Shrinkage
Two stages of solidification:
Nucleation
Growth
The best answer to fill in the blank would be B) Small intestine or the second option.
Answer:
Thermosensitive liposomes (TSL) are promising tools used to deliver drugs to targeted region when local hyperthermia is applied (∼40–42°C) which triggers the membrane phase transformation from a solid gel-like state to a highly permeable liquid state. Selective lipid components have been used to in TSL formulations to increase plasma stability before hyperthermia and speed drug release rate after. Two generations of TSL technology have been developed. The traditional thermal sensitive liposomes (TTSL) have utilized DPPC and DSPC as a combination. The second generation, lysolipid thermally sensitive liposomes (LTSL) technology, has been developed with incorporation of lysolipids that form stabilized defects at phase transition temperature. LTSL maintains certain favorable attributes:
High percentage of lysolipids incorporation;
Minimum leakage for therapeutical drugs encapsulation;
Ultrafast drug release upon heating (3.5 times enhanced compared to TTSL). For example, ThermoDox, a commonly used LTSL drug for cancer, has been reported to release 100% of the encapsulated doxorubicin within 30s;
First and most successful formulation for intravascular drug release.
Explanation:
https://www.creative-biostructure.com/Lysolipid-Thermally-Sensitive-Liposomes-Production-612.htm
To limit the hazard of creating nephrotoxicity, the patient should remain all around hydrated by drinking no less than eight 8-oz glasses of water day by day. Eating light dinners or taking the medication on an unfilled stomach would not diminish the hazard of creating nephrotoxicity. A medical attendant ought to never change the medication measurement without counseling the prescriber.
