What is one possible reason that Mutation 2 leads to the production of normal blood cells rather than the sickled blood cells?
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The first conformer cis-isomer (Picture 1) has both substituents in equatorial positions. Other conformer (on the right) has both substituents in axial positions. The conformer with both substituents in equatorial positions is more stable.
Trans isomers have one substituent in an equatorial position and the other in an axial position (Picture 2). The conformer with the tert-butyl group in the equatorial position is more stable because tert-butyl group is larger.
