Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
If people continue to kill baby deer then the population will start to decrease and if they stop killing them then the deer population will increase. If the deer population increase than that won't be a good thing for the environment because they will then be everywhere. Plus where there is prey there is predator so the predators of the deer will also increase in population.
Because they are the essential micronutrients for the different metabolites of living organisms?
The right answer is A patient who is Rh– can receive only Rh– blood.
The blood group is not the only thing that matters, it adds a category: rhesus. Rhesus refers to a red blood cell antigen that is on their wall. There are two blood group systems: Rh positive (Rh +) and Rh negative (Rh-).
Rhesus is positive in people who have this antigen. It concerns the majority of the population. Negative rhesus refers to people without the antigen. This rhesus factor is especially useful to know if a blood transfusion is feasible between two people.
The blood transfusions can be "iso-rhesus", that is to say between Rh + and Rh- but only in one sense: Rh- can give to Rh + but Rh + can not give to Rh-. Again because of the presence of antibodies directed against the antigen in Rh- people.
Answer:
I am pretty sure.. it's option B.
COBALT.
