Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
Meiosis | Ploidy | Life Cycles | Phases of Meiosis | Prophase I | Metaphase I ... (for example, one diploid 2n cell producing two diploid 2n cells; one haploid n cell producing ... is sporophyte, while pollen and ovaries contain the male and female ...
Explanation:
Answer:
1. The body uses fat as a fuel source, and fat is the major storage form of energy in the body.
2. helping to strengthen certain structures or bringing oxygen to the body's cells.
3. Your body uses water in all its cells, organs, and tissues to help regulate temperature and maintain other bodily functions.
Answer:
Cell theory refers to the idea that cells are the basic unit of structure in every living thing. Development of this theory during the mid 17th century was made possible by advances in microscopy. This theory is one of the foundations of biology.
Question: Many molecules are moved through the body by?
Answer:<u> The molecules are moved through the body by uses special transport proteins to move molecules across the membrane that cannot pass thorough on their own. Usually large molecules. Carrier proteins blind and carry the molecules across the cell membrane. They provide an open channel of passageway through the cell membrane for molecules to move across.</u>
<em>Hope this helps!.</em>
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<em>~A.W~ZoomZoom44</em>
