The most abstract plans depend on the Anterior areas of the frontal lobes, and the most concrete plans depend on the posterior areas of the frontal lobe. The frontal lobe is the part of the brain that controls important cognitive skills in humans, such as emotional expression, problem solving, memory, language, judgement, and sexual behaviors. It is the "control panel" of our personality and our ability to communicate.
For chemical reactions where the free energy of the reactants is much greater than the free energy of the products (DGo' < 0), the reaction proceeds spontaneously and the net result is a large ratio of product to reactant (large Keq).
