If you have just eaten, your body will secrete insulin. Insulin is the hormone that allows glucose to enter cells. That way they will have the proper energy for their normal functions.
If you have not eaten for a while, your body is running out of glucose to feed the cells so it needs to secrete another hormone called glucagon. This hormone is the complete opposite of insulin because it breaks down glycogen, proteins and fats into glucose.
The larger cell would be able to get rid of the waste faster! The greater the surface-area to volume ratio of a cell, the easier it is for the cell to get rid of wastes and take in essential materials such as oxygen and nutrients through the plasma membrane!