Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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The observation from the first question would tend to disprove the idea that evolution is based on b. inheritance of acquired characteristics because according to the experiment <span>theory of <span>adaptation was taken as a basis.
The answer for the next question is definitely adaptation as at first every live -being should get used to its environment in order to develop and so on.</span></span>
Parasitism bc the warbler's young are being displaced which means that the warblers are suffering harm through the loss of their young.
Answer:
Nucleic Acids are precursor for Proteins.
Explanation:
Proteins are formed( protein units called amino acids) by the decoding of specific nucleic acids to give specific Proteins.
No nucleic acids don't provide energy, these are building block of genetic material (DNA). While Proteins provide energy.
No proteins don't carry genetic information.
Yes structure of protein is determined by nucleic acids because each nucleic acids code fir specific unit of amino acid which join to form protein.
No subunits of nucleic acids are nucleotides where as subunits of Proteins are called amino acids.
Please mark it branliest if the answer is little bit satisfying.
Answer:
If you have something like an endoscope except controlled remotely doctors and healthcare workers could in essence use it as a sort of reconnoissance tool for diagnosing injuries and illnesses.
Explanation:
