Question

How does the response to acetylcholine in the presence of nifedipine compare to the response to acetylcholine without nifedipine? what response is there to nifedipine by itself (if any)?

Answer 1

Nicotinic acetylcholine receptors (nAChR), are ligand-gated ion channels and they can be a Na+, K+ and Ca2+ ion channel. Since nifedipine is a Ca2+ channel blocker (Ca2+ channel antagonist), it might inhibit the response of acetylcholine (if its receptor is Ca channel).