It's asking how the westward expansion effected the native americans. A lot of it resulted in many native americans losing their homelands & being violently suppressed. They were forced out of the regions where they lived. A lot were killed from battles & diseases (diseases brought from the europeans). They wanted to keep their land that was being taken from them, hence the reason for the battles which resulted in many native americans lives being lost.
Baron de Montesquieu's view of separation of powers greatly influenced the Founding Fathers. He believed the government must separate powers to run effectively and fairly.