Answer:
The correct answer is "5-1-3-2-4".
Explanation:
Internalization of LDL particles into cells, is needed to form the intracellular vesicles known as endosomes. The order of events that allow for this process are:
5) LDL receptors migrate to the cell surface and cluster in clathrin-coated pits. Clathrin acts directing the receptors to the cell membrane region where endosomes are formed.
1) A combination of cholesterol and apolipoprotein binds to LDL receptors and becomes internalized as endocytotic vesicles. Once the receptors are in the proper cell membrane region, cholesterol and apolipoprotein are bound and internalized.
3) Several endocytotic vesicles fuse to form an endosome.
2) The environment of the endosome becomes acidic, which causes the LDL to dissociate from its receptor; additionally, the endosome fuses with a lysosome. LDL should be dissociated from its receptor since it is going to be degraded in the following step.
4) The LDL particle is degraded by the lysosome. This takes place after endocytosis, when LDL particles are transported into lysosomes once they are fused, cleaving the cholesterol esters into cholesterol and fatty acids.
The statement 'interactions of the hydrophobic and hydrophilic amino acids help to anchor the protein in the membrane' explains why protein folding is critical. This process is fundamental for the function of transmembrane proteins.
Protein folding refers to the process by which a polypeptide (i.e., a protein) adopts its final tridimensional 3D shape (conformation).
In a protein, some amino acids contain hydrophilic R groups, whereas other amino acids contain hydrophobic R groups.
During protein folding, hydrophobic amino acids are arranged so they can interact with the long chains of the fatty acids in the internal region of the lipid bilayer, whereas hydrophilic amino acids are arranged so they interact with water on the surface of the cell membrane.
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It must be durable and available
The correct codes are 63267 and 69990.
The codes are given based on the lesion if it is intradural or extradural. In our case here it is extradural cystic structure so that is why it ranges between 63265 to 63268.
We also divide the section of spine depending on where the lesion is being located. Code 63267 describes laminectomy which has evacuation of intraspinal lesion which is found in the lumbar spine.
69990 code documents the use of microscope.
