Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
Megaspore—2n.
Explanation:
Angiosperms are the fruit bearing plants and reproduce by the process of sexual reproduction. The chromosome number are specific at each stage of the cell cycle of the angiosperms.
Microspores , egg are haploid. Zygote is diploid in nature. Megaspores get germinate into the female gametophytes and these are haploid in nature. Megaspores are also haploid in angiosperms.
Thus, the correct answer is option (b).
Answer: Only 10 percent of energy in a light bulb is used to create light. ...
The amount of energy Americans use doubles every 20 years. ...
Explanation:
The f1 generation may have genes for short plants just that the genes for long plants are dominant over the genes for short plants(recessive) so when cross pollination happen and that two f1 long plants which are homozygous cross pollinate, the recessive genes have a chance of being paired up in new offspring(F2 offspring) thus the possiblity of short plants in f2 generation
An increase in the permeability of the cells of the collecting tubule to water is due to an increase in production of ADH. Hormone ADH also called vasopressin is responsible for regulating the amount of water in the blood and is released from the pituitary gland based on signals from the hypothalamus, which detects the water levels of the blood. When too much water is in the blood, the hormone release is decreased and more water is excreted in the kidneys and thus increasing urine output.
