I believe the structure organelle that may be faulty is Mitochondria. Mitochondria is a cellular organelle that is involved in cellular respiration a process that uses glucose to yield water and carbon dioxide coupled with production of energy in the form of ATP. Melas meaning mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes is a conditions that affects body systems especially the brain and the nervous system and muscles.
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If the mutation is beneficial, the mutated organism survives to reproduce, and the mutation gets passed on to its offspring. In this way, natural selection guides the evolutionary process to incorporate only the good mutations into the species, and expunge the bad mutations.
The basic unit of temp. is the degree, which could be Celcius, Fahrenheit or Kelvin.