I think it's oxygen and water because they are the substance for cellular respiration.
The answer is carbonic acid-bicarbonate buffer. This buffer system is regulated by the lungs and kidneys due to the regulation of CO2 and bicarbonate ions respectively. It is formed by the dissolving of carbon dioxide from the tissue into the blood plasma. A weak acid-base conjugate is a good buffer due to its partial dissociation in water.
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In addition to erythropoietin, red blood cell production requires adequate supplies of substrates, mainly iron, vitamin B12, folate, and heme. RBCs survive about 120 days.
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to be honest I don't really know the answer but i would go with D because of cell respiration makes sense to me
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