Function of an enzyme is to lower reaction's activation energy and to increase speed of a reaction, but to make it happen, enzyme and substrate must fit spatially. The shape of an enzyme is essential to make enzyme-substrate complex - if active site of an enzyme doesn't fit to substrate, there won't be a enzyme-catalised reaction.
Mutations can be categorized based on the kind of effect they have on an organism. Blue eyes in humans are a result of a mutation in the OCA2 gene, which controls the production of pigment melanin in the iris.
This mutation is an example of a neutral mutation. Such mutations have no effect on an organism’s survival.
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Explanation:
It binds lactose which changes its conformation so that is no longer binds to DNA. This allows the lactose operon to be transcribed.
