Answer:
When you change the order of the base pairs in an organism, that is called a mutation. There are three types of mutations: a deletion, an addition, and a substitution. In a deletion, one of the three bases in a codon is pulled out, or deleted.
Explanation:
Answer:
Why does the speaker in this excerpt from Langston Hughes's "I, Too" wish to eat at the table?
Tomorrow,
I'll be at the table
When company comes.
Nobody'll dare
Say to me,
"Eat in the kitchen,"
Then.
A.
The speaker hopes to sit at the table and interact with those he serves from the kitchen.
B.
The speaker resents being sent to the kitchen and wants an equal seat at the table with other people.
C.
The speaker hopes to rise above those now at the table and force them to eat in the kitchen later.
D.
The speaker is uncomfortable while eating alone in the small kitchen.
E.
The speaker is proud to be in the kitchen because he is serving the guests at the table.
Explanation:
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Well, the cell would be out of energy! The mitochondria plays a very important role in cell functions. With out it, it cannot do whatever job that needs to be acquired.
Answer:
it regulates blood volume and blood pressure.
Explanation:
