Dragonflies are most closely related to damselflies. Damselflies are smaller, slimmer, and most of them fold their wings along their body when they are resting.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
Answer:
1/2
Explanation:
Ggrr gives Gr, Gr, gr, gr
ggRR gives gR only.
So, the combination would be <u>GrRr</u>, <u>GrRr</u>, ggRr, ggRr
To have both dominant traits, the child has to GG or Gr, and RR or Rr
2/4=1/2
The most abundant element in the atmosphere can also be is nitrogen since nitrogen gas accounts for about 78% of the atmospheric gases. Beans and whey protein are, of course, high in protein, and a fundamental component of proteins at the molecular level is a nitrogen-containing group called an amine group.
Hello!! I always remember recessive genes as someone having a passive personality and dominant genes as having an assertive personality. Therefore, dominant genes would mask others when present because they have that assertive personality. If you think about it as babies, when their dad has darker hair and the mother has lighter hair, the baby will most likely have darker hair because the darker hair is the dominant gene. I would say that the answer would be false. If you are having trouble understanding, you can always make a Punnett square and see what your outcomes are. I hope I helped. Have a great day!!
