Answer: Christopher Columbus and Fernando Magellan.
Explanation:
Christopher Columbus was born in Genoa (Italy). He ended up in a combination of life circumstances in Portugal and then in Spain. Christopher Columbus discovered America in 1492. He sailed under the banner of the King of Spain. With this discovery, Columbus gained a great deal of popularity in Spanish. Columbus was convinced that he was in the waters of Asia, in fact at the time of his arrival, he was in the Bahamas.
Fernando Magellan was born in Portugal. In the sixteenth century, Portugal introduced big names in the world of seafaring and exploration. Magellan was enthusiastic, and to sail the world, he sought the help of the Portuguese king. After the king rejected his plan, he presented the King of Spain to Charles V. The king enthusiastically accepted him because Portugal was the direct rival of Spain. Thus, in about 1519, Fernando Magellan led the first expedition to sail the world.
The Black Death killed 38 million people, it was a terrible illness which spread rapidly.
The Great Schism was in 1054 and the Christian church broke up into two sections, which essentially divided the Church with two popes.
I would say that trade would be "believed to travel to Europe because of this", because it would not really fit anywhere else.
Now, I'm not two sure on the last one but the Hundred Years War was where King Edward the III of England thought that he should be the king of France, so there was a very long battle between the two. I would say the Hundred Years War would be started by division of the heir to the throne of England, and France and Italy did not agree who was to be pope. Since the Hundred Years War had really nothing to do with Italy.
I believe the answer would be D (all of the above).