<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Plantae: Autotrophic, Multi- or Monocellular, have cell walls as well as a membrane, have a chloroplast making the characteristic green color and to capture sunlight for photosynthesis. Break down generated glucose into it's components.
Animalia: Heterotrophic, Multi- or Monocellular, have a cell membrane made of a phospholipid bilayer, and many mitochondria to aid with movement energy. Feed on plants or other animals. Eukaryotic cells.
Fungi: Heterotrophic, most Multicellular, have a rigid cell wall made of chitin, specialized cells to aid with decomposition of dead organic matter. Eukaryotic cells.
Protista: Can be plant-like, animal-like, or fungus-like. Most are single-celled, may be chemosynthetic or photosynthetic. Eukaryotic cells.
Archeabacteria: Prokaryotic. Do not have nuclei or membrane-bound organelles. Move around using a flagellum to propel itself. Lives in mainly fluid environments (air, water). Separated from Eubacteria due to it's high tolerance of extreme conditions, such as high salinity, no oxygen, burning heat, or freezing cold. Can be chemosynthetic or anaerobic, as well as aerobic.
Eubacteria: Normal, everyday bacteria. Prokaryotic, chemosynthetic, anaerobic, or aerobic. Do not have nuclei or membrane-bound organelles. Mobile using a flagellum to propel itself.
Explanation:
amphibians have smooth, sticky wet and highly porous skin to perform various functions.
reptiles have a dry, hard and scaly skin, which guards them in harsh conditions.
amphibians lay their eggs in water and cover them with gel.
reptiles lay their eggs on land and have a hard protective shell.
