<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Answer:
Plant species it eats
Explanation:
The 1st, 3rd, and 4th are describing its surroundings not the individual grasshopper.
Answer:
Taking antibacterial drugs for viral infections
Explanation
This is called a misuse of antibacterials also popular known as antibiotics. This results in an increased chance of bacteria developing mutations against the antibacterial hence rendering the drugs ineffective in treatment. They also form the risk of causing dangerous mutations that turn harmless bacteria into harmful bacteria.
Answer:
I believe it will be D. all of the above.
Explanation:
The cytoplasm of a bacterial cell contains the deoxyribonucleic acid (DNA) molecules that make up the bacterial genome (or nucleoid), the transcriptional machinery that copies DNA into ribonucleic acid (RNA), and the ribosomes that translate the messenger RNA information into protein sequence.
