Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Fuel cells can make an electricity from a simple electrochemical
reaction in which oxygen and hydrogen combine to form water. There are several
different types of fuel cell but they are all based around a central design
which consists of two electrodes, a negative anode and a positive cathode.
These are separated by a solid or liquid electrolyte that carries electrically
charged particles between the two electrodes. A catalyst, such as platinum, is
often used to speed up the reactions at the electrodes. Fuel cells are
classified according to the nature of the electrolyte. Every type needs
particular materials and fuels and is suitable for any applications. The
article below uses the proton exchange membrane fuel cell to illustrate the
science and technology behind the fuel cell concept but the characteristics and
applications of the other main designs are also discussed. Proton Exchange Membrane Fuel Cells (PEMFC)
The hydrogen ions permeate across the electrolyte to the
cathode, while the electrons flow through an external circuit and provide
power. Oxygen, in the form of air, is supplied to the cathode and this combines
with the electrons and the hydrogen ions to produce water. These reactions at
the electrodes are as follows:
Anode: 2H24H+ + 4e-
Cathode: O2 + 4H+ + 4e- 2H2O
Overall: 2H2 + O22H2O + energy
PEM cells operate at a temperature of around 80°C. At this
low temperature the electrochemical reactions would normally occur very slowly
so they are catalysed by a thin layer of platinum on each electrode.
Answer:
potential benefit: more nutritious food
potential negative impact:biodiversity loss
Cell wall is the outer permeable covering in all pants and almost all prokaryotes ! cell wall are mainly made up of cellulose , sometime by chitin!!
Answer:They have a large number of mitochondria.
